"If we knew what it was we were doing, it wouldn't be called 'research,' would it?",
Doctoral student at Computer Science Department, The Graduate Center, CUNY
Adjunct Lecturer, Computer Science Department, Hunter College, CUNY.
(please, send teaching related
mail to this address)
The Graduate Center, CUNY
Computer Science Department,
365 5th Avenue
NY, NY 10016
I am currently working with Distinguished Professor Gabor Herman in Discrete Imaging and Graphics Group. My general research interest are in image reconstrction from projections and its applications in biomedical imaging. More specifically, I am working on reconstructions in electron microscopy. We are interested in developing reconstruction methods that take into account and correct for the distance-dependent blurring that occurs during imaging process of a molecule by electron microscope.
In December 1959, Richard Feynman said in his famous speach "There’s Plenty of Room at the Bottom":
"The electron microscope is not quite good enough, with the greatest
care and effort, it can only resolve about 10 angstroms. I would like
to try and impress upon you while I am talking about all of these
things on a small scale, the importance of improving the electron
microscope by a hundred times. It is not impossible; it is not against
the laws of diffraction of the electron. The wave length of the
electron in such a microscope is only 1/20 of an angstrom. So it should
be possible to see the individual atoms. What good would it be to see
individual atoms distinctly? ..."
Today the resolution of some electron microscopes reached 0.5 of an Angstrom.
As the technology of electron microscopy improves and the need for imaging
larger specimens emerges, an imperfection of electron microscopes that
has not been considered important is likely to become an essential
limitation. This imperfection is due to the fact that the way electron
microscopy blurs the object to be imaged is not uniform, but changes
with the distance of a specimen layer from the electron source.
Variation in blurring that occurs within a single specimen can be
ignored when the imaged structures are of a small size and when the
desired resolution in the reconstructed structure is not high. Recent
advances in electron microscopy technology provide us with the
potential of achieving atomic resolution, but reconstruction algorithms
developed under the assumption of uniform blurring throughout the
entire structure applied to real electron microscopic data will fail to
achieve this (except possibly in the case of smaller molecules). This
limitation can be removed if the images obtained by electron
microscopes are corrected for the variable blurring before the
reconstruction process, or if such correction takes place during the
Read more about 3D electron tomography reconstructions and some of